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Analysis of the group A Streptococcus CcpA Transcriptome

ABSTRACT: This study evaluate how catabolite control protein A (CcpA) inactivation affected gene transcript levels in the group A Streptococcus serotype M1 strain MGAS5005 during growth in standard laboratory medium. Keywords: transcriptome analysis

ORGANISM(S): Streptococcus pyogenes Streptococcus sp. 'group A'

PROVIDER: GSE10156 | GEO | 2008/01/30

SECONDARY ACCESSION(S): PRJNA108349

REPOSITORIES: GEO

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Analysis of the group A Streptococcus CcpA Transcriptome

Project description:This study evaluate how catabolite control protein A (CcpA) inactivation affected gene transcript levels in the group A Streptococcus serotype M1 strain MGAS5005 during growth in standard laboratory medium. Keywords: transcriptome analysis 4 replicates of strain MGAS5005 and delta_cppA were grown in THY to early and late logarithmic growth phases. The transcriptomes of each samples were then analyzed.

2010-05-26 | E-GEOD-10156 | biostudies-arrayexpress

MGAS5005 vs MGAS5005∆ccpA

2008-06-04 | GSE11328 | GEO

MGAS5005 vs MGAS5005∆ccpA

Project description:The aim of this study was to determine the extent of the CcpA regulon in the M1 serotype MGAS5005. Kinkel and McIver, 2008 Infection and Immunity Keywords: group A streptococcus, CcpA 3 biological replicates of MGAS5005 and the isogenic ∆ccpA strain were grown, and RNA was isolated independently 3 times. The RNA was converted to cDNA and labeled with with either Cy3 or Cy5 using the GE Healthcare CyScribe Post-labelling kit. The arrays were scanned with GenePix 6.1 and analyzed with Acuity 4.0.

2008-06-04 | E-GEOD-11328 | biostudies-arrayexpress

Evaluation of ccpA deletion on global gene expression of three M serotype strains of group A streptococcus

Project description:We sought to determine how deletion of ccpA affects the gene expression profile in three M serotype strains of group A streptococcus

2017-02-10 | GSE84641 | GEO

ccpA mutant compared to D39 wild-type in Streptococcus pneumoniae in CDM + Galactose at MID-log growth phase

Project description:Comparison of Streptococcus pneumoniae D39 ccpA mutant compared to D39 wild type in CDM with galactose as sole carbon source to define the regulon of carbon catabolite control protein CcpA under this condition Details described in Carvalho SM, Kloosterman TG, Neves AR, Kuipers OP. CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae. Plos One 2011

2011-10-01 | GSE31817 | GEO

ccpA mutant compared to D39 wild-type in Streptococcus pneumoniae in CDM + Glucose at MID-log growth phase

Project description:Comparison of Streptococcus pneumoniae D39 ccpA mutant compared to D39 wild type in CDM with glucose as sole carbon source to define the regulon of carbon catabolite control protein CcpA under this condition Details described in Carvalho SM, Kloosterman TG, Neves AR, Kuipers OP. CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae. Plos One 2011

2011-10-01 | GSE31815 | GEO

ccpA mutant compared to D39 wild-type in Streptococcus pneumoniae in CDM + galactose at transition-phase of growth (TS)

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ccpA mutant compared to D39 wild-type in Streptococcus pneumoniae in CDM + GLucose at transition-phase of growth (TS)

2011-10-01 | GSE31816 | GEO

Comparison of the CcpA and CovR Transcriptomes in Group A Streptococcus

Project description:The goal of this study were to compare the transcriptoms of CcpA and CovR in group A Streptococcus. Isogenic mutant strains were created in which CcpA and CovR were inactivated alone and in combination. The transcriptomes of the four strains (wild-type, CcpA mutant, CovR mutant, and ccpA-covR double mutant) were then compared.

2010-03-01 | GSE20212 | GEO

RNA-seq of a Streptococcus agalactiae A909 mutant strain deleted for the pleiotropic transcriptional regulator CcpA

Project description:The commensal bacterium Streptococcus agalactiae is responsible for various infections in a wide variety of hosts including humans. Its broad spectrum of hosts shows its ability to acquire nutrients in variable conditions. The carbon catabolite repression allows bacteria to prioritize the uptake and the catabolism of the environmental sugars. In Gram-positive bacteria, CcpA (catabolite control protein A), a pleiotropic transcriptional regulator, plays a key role in catabolite repression. Studies have shown the involvement of carbon catabolite repression in the adaptation and stress resistance of pathogenic bacteria. The goal of this study is to determine the regulon and the role(s) of CcpA in the physiology and adaptation of S. agalactiae. To this aim, Streptococcus agalactiae strain A909 WT and its isogenic mutant ∆ccpA, obtained by allelic exchange were grown in filter-sterilized chemically defined medium (CDM) supplemented with 0,25% or 1% (w/v) of glucose. Their transcriptomes were compared under these two conditions by using RNA-seq.

2022-07-12 | E-MTAB-11639 | biostudies-arrayexpress

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