Transcriptomics,Genomics

Dataset Information

146

Genome-wide association study and transcriptome analysis of the white/red earlobe color in Qingyuan Partridge chicken


ABSTRACT: Gene expression comparison between red group and white group (Red_vs_White) showed that there were 81 differentially expressed genes (DEGs) (fold changes ≥ 1.5; adjusted P-value < 0.05) between the two samples, in which 27 were up-regulated and 54 were down-regulated. Further functional analysis on DEGs showed that, no significant KEGG pathways or GO terms could be clustered, but a number of genes including TP63 etc, could be clustered into HPO terms of Thickened skin, Epidermal thickening, Hyperkeratosis, Dry skin and Alopecia Overall design: Earlobes from 3 male 114-day QYPs exhibiting white earlobe color and 3 male 114-day QYPs exhibiting red earlobe are separately collected for RNA-seq

INSTRUMENT(S): Illumina HiSeq 2500 (Gallus gallus)

SUBMITTER: Wei Luo  

PROVIDER: GSE101622 | GEO | 2018-03-27

REPOSITORIES: GEO

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Publications

Genome-Wide Association Study and Transcriptome Analysis Provide New Insights into the White/Red Earlobe Color Formation in Chicken.

Luo Wei W   Xu Jiguo J   Li Zhenhui Z   Xu Haiping H   Lin Shudai S   Wang Jiaying J   Ouyang Hongjia H   Nie Qinghua Q   Zhang Xiquan X  

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20180425 5


BACKGROUND/AIMS:Earlobe color is a typical external trait in chicken. There are some previous studies showing that the chicken white/red earlobe color is a polygenic and sex-linked trait in some breeds, but its molecular genetic and histological mechanisms still remain unclear. METHODS:We herein utilized histological section, genome-wide association study (GWAS) and RNA-seq, further to investigate the potential histological and molecular genetic mechanisms of white/red earlobe formation in Qiang  ...[more]

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