Genomics

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Primary melanoma cell lines vary in glycolytic activity


ABSTRACT: Some patients with metastatic melanoma respond very well to adoptive T-cell therapy (ACT) based on re-infusion of autologous, ex vivo-expanded tumor-infiltrating T lymphocytes (TILs) plus interleukin-2 (IL-2). However, responses are highly variable. We found that glycolysis in primary melanoma tumor cell lines, as measured by metabolic assays or expression of glycolysis genes, was strongly associated with clinical resistance of the corresponding patients' tumor to ACT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE101644 | GEO | 2018/03/01

REPOSITORIES: GEO

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