Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA methylation in demyelinated multiple sclerosis hippocampus

ABSTRACT: Genome wide DNA methylation profiling of genomic DNA isolated from hippocampus of multiple sclerosis patients were hybridized to Illumina HumanMethylation450 Beadchip arrays. DNA methylation profiles across approximately 45,000 CpGs were compared between 8 myelinated and 7 demyelinated tissues .

ORGANISM(S): Homo sapiens

PROVIDER: GSE101658 | GEO | 2017/09/14

SECONDARY ACCESSION(S): PRJNA395092

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions [methylation]

Project description:We compared genome-wide DNA methylation profiles between chronically demyelinated MS lesions and matched normal-appearing white matter (NAWM).

2023-06-29 | GSE224455 | GEO

DNA methylation in demyelinated multiple sclerosis hippocampus.

Project description: Not available

| S-EPMC5562763 | biostudies-literature

Gene expression of white and grey matter demyelinated areas and normal appearing matter from Multiple Sclerosis leukocortial lesions of human post-mortem tissue

Project description:Using laser capture microscopy, white (WM) and grey matter (GM) demyelinated areas and normal appearing matter was collected from histologically verified leukocortical lesions from snap-frozen human post mortem tissuederived from Multiple Sclerosis patients. Our data shows large differences in gene expression in WM and GM demyelinated areas (compared to their respective normal appearing matter) even when the demyelinated areas are spatially connected such as in leukocortical lesions. Thus, we show that WM demyelinated areas and GM demyelinated areas are distinct entities with distinct pathology. Therefore findings observed in WM demyelinated areas cannot be generalized to GM demyelinated areas.

2022-01-02 | GSE149326 | GEO

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions [RNA-seq]

Project description:We compared transcriptomic profiles between chronically demyelinated MS lesions and matched normal-appearing white matter (NAWM).

2023-06-29 | GSE224377 | GEO

Array-based determination of DNA methylation in children born small for gestational age

Project description:Genome wide DNA methylation profiling of peripheral blood samples obtained from normal controls and children born SGA. Illumina's HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 450.000 CpGs. Bisulphite converted DNA from the 110 samples were hybridised to the Illumina HumanMethylation450 Beadchip.

2016-07-03 | E-GEOD-47880 | biostudies-arrayexpress

Array-based determination of DNA methylation in children born small for gestational age

2016-01-01 | GSE47880 | GEO

Project description:Genome-wide DNA methylation level was studied to identify the clustering of correlated DNA methylation at CpGs in whole blood. We used Illumina HumanMethylation450 BeadChip array to identify the clustering of correlated DNA methylation in whole blood from normal individuals from Baltimore Longitudinal Study of Aging (BLSA). Bisulphite converted DNA from normal individuals were hybridized to the Illumina Illumina HumanMethylation450 BeadChip arrays

2014-03-25 | E-GEOD-54882 | biostudies-arrayexpress

The tissue is the issue: Improved methylome analysis from paraffin-embedded tissues by application of the HOPE-technique

Project description:Genome wide DNA methylation profiling of DNA samples obtained from normal lung tissue and lung carcinoma, either fixed by formalin (FFPE), HOPE (paraffin embedded) or cryo-preserved. Illumina's HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 450.000 CpGs. Bisulphite converted DNA from the 36 samples were hybridized to the Illumina HumanMethylation450 Beadchip.

2016-08-22 | E-GEOD-51077 | biostudies-arrayexpress

Epigenome analysis of 65 CID cases

Project description:Genome wide DNA methylation profiling of 65 congenital imprinting disorder samples, 45 BWS and 22 SRS. The Illumina Infinium HumanMethylation450 BeadChips was used to obtain DNA methylation profiles across approximately 485,000 CpGs in blood samples.

2021-05-01 | GSE166531 | GEO

Epigenetic and transcriptomic signature of aging in human liver [methylation]

Project description:Genome-wide DNA methylation profiling of liver biopsies collected from 45 healthy liver donors ranging from 13 to 90 years old. The Infinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 470,000 CpGs.

2018-09-11 | GSE107038 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data