Genomics

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Role of DPYSL2A in KLF4-mediated monocytic differentiation in AML cells


ABSTRACT: To compare the global gene expressions in between KLF4- and DPYSL2A-expressed AML cells, we conducted gene expression arrays in THP-1 cells lentivirally-transduced with doxycycline-inducible KLF4 or DPYSL2A. We identified the pivotal role of KLF4-DPYSL2A axis in differentiating AML cells, which could be theraputically-tageted in conventional therapy-resistant AML patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE101751 | GEO | 2020/05/31

REPOSITORIES: GEO

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