Genomics

Dataset Information

32

Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina ratRef-12 v1.0 expression beadchip

SUBMITTER: Karl Eric Herbert  

PROVIDER: GSE101847 | GEO | 2017-07-26

SECONDARY ACCESSION(S): S-EPMC5610037PRJNA395691 GSE101845 GSE101844

REPOSITORIES: GEO

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Publications

Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle.

Dott William W   Wright Jayne J   Cain Kelvin K   Mistry Pratibha P   Herbert Karl E KE  

Redox biology 20170918


There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel xenobiotics. To this end, an in vitro rat skeletal muscle model (L6) was used to study the translation of transcriptomics data generated from an in vivo rat model. Novel sulfonyl isoxazoline herbicides were associated with skeletal muscle toxicity in an in vivo rat model. Gene expression pathway analysis on skeletal muscle tissues taken from in vivo  ...[more]

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