Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of differentially expressed miRNAs of exosome-like microvesicles secreted from mouse colon cancer stem cells

ABSTRACT: As accumulating evidence suggests cancer cells exhibit stem-like properties for advanced diseases and cancer stem cells (CSCs) have been identified in various tumor types, revisiting present knowledge toward CSCs is essential. The identification of exosome-loaded miRNAs responsible for stemness and chemoradioresistance of CSCs should eventually leadd to development of novel therapeutic approaches.

ORGANISM(S): Mus musculus

PROVIDER: GSE101950 | GEO | 2020/07/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Identification of differentially expressed miRNAs in exosomes secreted from human colon cancer stem cells.

Project description:As accumulating evidence suggests cancer cells exhibit stem-like properties for advanced diseases and cancer stem cells (CSCs) have been identified in various tumor types, revisiting present knowledge toward CSCs is essential. The identification of exosome-loaded miRNAs responsible for stemness and chemoradioresistance of CSCs should eventually leadd to development of novel therapeutic approaches.

2021-07-01 | GSE117479 | GEO

Nuclear exosome

Project description:Nuclear exosome

| PRJNA304634 | ENA

An in situ ascorbate peroxidase 2-based labeling method and its application in detecting exosome proteins released from mouse proximal tubule cells under oxidative stress

Project description:Here, we developed an in situ labeling approach to identify exosome-loaded proteins, which bypasses the traditional exosome isolation steps. In this method, an engineered ascorbate peroxidase targeting to endosomes-destined exosomes was used to label proteins loaded inside exosomes released from kidney proximal tubule-derived cells. Mass spectrometry analysis of the kidney proximal tubule-derived cells identified oxidative stress-induced exosome proteome alteration.

2022-08-12 | PXD025852 | Pride

The miRNA expression of exosome secreted by human urine-derived stem cells

Project description:The miRNA expression of exosome secreted by human urine-derived stem cells

| PRJNA849505 | ENA

Lung Spheroid Cell and Mesenchymal Stem Cell Exosome Proteome

Project description:Human lung spheroid cell and human mesenchymal stem cell exosome proteome

2019-11-18 | MSV000084596 | MassIVE

NRDE2 negatively regulates nuclear exosome functions

Project description:The exosome functions in the degradation of diverse RNA species, yet how it is negatively regulated remains largely unknown. Here, we show that NRDE2 forms a 1:1 complex with MTR4, a nuclear exosome cofactor critical for exosome recruitment, via a conserved MTR4-interacting domain (MID). Unexpectedly, NRDE2 mainly localizes in nuclear speckles, where it inhibits MTR4 recruitment and RNA degradation, and thereby ensures efficient mRNA nuclear export. Structural and biochemical data revealed that NRDE2 interacts with MTR4's key residues, locks MTR4 in a closed conformation, and inhibits MTR4 interaction with the exosome as well as proteins important for MTR4 recruitment, such as the cap-binding complex (CBC) and ZFC3H1. Functionally, MID deletion results in the loss of self-renewal of mouse embryonic stem cells. Together, our data pinpoint NRDE2 as a nuclear exosome negative regulator that ensures mRNA stability and nuclear export.

2019-03-14 | GSE120206 | GEO

Rosa Damascena Stem Cell-derived Exosome

Project description:Analysis of Rosa Damascena Stem Cell-derived Exosome

2023-08-21 | PXD043169 | Pride

miRNAs in MSCs-exosome compared with NIH3T3-exosome

Project description:miRNAs in MSCs-exosome compared with NIH3T3-exosome

| PRJNA752363 | ENA