Genomics

Dataset Information

20

CDNA aCGH study of pure DCIS without invasive tumor, DCIS associated with IDC and its IDC component


ABSTRACT: cDNA aCGH study of pure DCIS (breast duct carcinoma in situ) without invasive tumor, DCIS associated with IDC (breast invasive duct carcinoma) and its IDC component 23 patients: 6 pure DCIS without invasive cancer and no history of invasive cancer, 17 DCIS associated with IDC. Out of the latter 1 tumor had only enough DCIS (#16) for aCGH and one - IDC (#23) Keywords: Comparative clinical study Overall design: Histological sections microdissected, DNA extracted, subjected to whole genome amplification protocol (SCOMP) and aCGH. The replicate raw data file GSM257548_2.gpr (dcis19_2.gpr) for GSM257548 is not available.

INSTRUMENT(S): UHN cDNA microarray

SUBMITTER: Susan Done   

PROVIDER: GSE10197 | GEO | 2009-02-01

SECONDARY ACCESSION(S): PRJNA108313

REPOSITORIES: GEO

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Publications

Genomic differences between pure ductal carcinoma in situ of the breast and that associated with invasive disease: a calibrated aCGH study.

Iakovlev Vladimir V VV   Arneson Nona C R NC   Wong Vietty V   Wang Chunjie C   Leung Stephanie S   Iakovleva Gaiane G   Warren Keisha K   Pintilie Melania M   Done Susan J SJ  

Clinical cancer research : an official journal of the American Association for Cancer Research 20080701 14


PURPOSE: In the quest for new targets, genomes of ductal carcinoma in situ (DCIS) and infiltrating duct carcinoma (IDC) have been compared previously; however, genomic alterations associated with cancer progression were difficult to identify. We hypothesized that significant events can be detected by comparing lesions with a broader range of behavior: from pure DCIS to IDC associated with lymph node metastasis. EXPERIMENTAL DESIGN: Array comparative genomic hybridization, calibrated by self-self  ...[more]

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