Genomics

Dataset Information

160

Deletion of 11q in neuroblastomas drives sensitivity to PARP inhibition [SEQ]


ABSTRACT: SNP arrays were combined with next generation sequencing (NGS) to precisely define the deleted region in 17 primary 11q-loss neuroblastomas and identify allelic variants in genes relevant for neuroblastoma aetiology. We assessed PARP inhibitor olaparib in combination with other chemotherapy medications using both in vitro and in vivo models. Overall design: Next generation sequencing of genes relevant for neuroblastoma aetiology and cancer

INSTRUMENT(S): Ion Torrent Proton (Homo sapiens)

SUBMITTER: Jaime Font de Mora  

PROVIDER: GSE101989 | GEO | 2017-07-28

SECONDARY ACCESSION(S): PRJNA396156

REPOSITORIES: GEO

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Publications

Deletion of 11q in Neuroblastomas Drives Sensitivity to PARP Inhibition.

Sanmartín Elena E   Muñoz Lisandra L   Piqueras Marta M   Sirerol J Antoni JA   Berlanga Pablo P   Cañete Adela A   Castel Victoria V   Font de Mora Jaime J  

Clinical cancer research : an official journal of the American Association for Cancer Research 20170822 22


Purpose: Despite advances in multimodal therapy, neuroblastomas with hemizygous deletion in chromosome 11q (20%-30%) undergo consecutive recurrences with poor outcome. We hypothesized that patients with 11q-loss may share a druggable molecular target(s) that can be exploited for a precision medicine strategy to improve treatment outcome.Experimental Design: SNP arrays were combined with next-generation sequencing (NGS) to precisely define the deleted region in 17 primary 11q-loss neuroblastomas  ...[more]

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