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Expression profile from mouse lung treated with B[a]P and LPS

ABSTRACT: Patients with inflammatory lung diseases are often additionally exposed to polycyclic aromatic hydrocarbons like B[a]P and B[a]P-induced alterations in gene expression in these patients may contribute to the development of lung cancer. Mice were intra-nasally treated with lipopolysaccharide (LPS, 20 μg/mouse) to induce pulmonary inflammation and subsequently exposed to B[a]P (0.5 mg/mouse) by intratracheal instillation We used RNA microarrays to detail the global gene expression change after each treatment. Meanwhile, compared the up- and down-regulated gene between the LPS&BaP and BaP in order to identify the role of inflammation on BaP induced carcinogenesis

ORGANISM(S): Mus musculus

PROVIDER: GSE102016 | GEO | 2017/07/29

SECONDARY ACCESSION(S): PRJNA396213

REPOSITORIES: GEO

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