KSHV vIRF3 promotes angiogenesis of lymphatic endothelial cells (LECs)

ABSTRACT: Herein, we report viral interferon regulatory factor 3 (vIRF3) as a pro-angiogenic factor together with HDAC5 that coordinates with LEC transcriptome, thus resulting in hyper-sprouting formation and ultimately leading to abnormal lymphangiogenesis. Overexpression of vIRF3 in LECs but not blood endothelial cells (BECs) exhibited a unique KSHV-associated angiogenic effect, evidenced by elongated spindle shape, sprouting, and tube formation. Furthermore, using vIRF3 knockout recombinant KSHV, we confirmed that vIRF3 is a critical factor of KSHV-mediated lymphangiogenesis in primary LECs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE102132 | GEO | 2017/12/19

SECONDARY ACCESSION(S): PRJNA396759

REPOSITORIES: GEO