Project description:The interaction between a pathogen and a host is a highly dynamic process in which both agents activate complex programs. Here, we introduce a single-cell RNA-Seq method (scDual-Seq) that simultaneously captures both host and pathogen transcriptomes and use it to study the process of infection of individual mouse macrophages with the intracellular pathogen Salmonella typhimurium. Among the infected macrophages, we found three subpopulations and we show evidence for a linear progression through these subpopulations, supporting a model in which these three states correspond to consecutive stages of infection.

2017-10-07 | GSE102161 | GEO

Single cell RNA Seq data of BMDM from mouse infected with Salmonella [dilution]

2017-10-07 | GSE102159 | GEO

Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-03-04 | E-GEOD-53932 | biostudies-arrayexpress

Single cell RNA Seq data of BMDM from mouse infected with Salmonella [stat log]

2017-10-07 | GSE102162 | GEO

Gene Expression data from mouse bone marrow derived macrophages infected by the promastigote form of Leishmania major parasite (P) or Killed parasite (Kp) during a time course of infection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-12-19 | E-GEOD-31997 | biostudies-arrayexpress

Expression data from mouse spleen pre-Red Pulp Macrophages (PreRPM), circulating Ly6C-low subset of monocytes (patrolling monocytes), and bone marrow derived macrophages (BMDM)