Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)
SUBMITTER: Gordon K Smyth
PROVIDER: GSE102227 | GEO | 2017-09-25
SECONDARY ACCESSION(S): PRJNA397054
REPOSITORIES: GEO
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GSE102227_Mcl1-GenewiseCounts.txt.gz | Txt | |||
GSE102227_RAW.tar | Raw | |||
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Blood 20170929 23
T-cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects in this process undermine immune function and tolerance. To uncover new strategies to restore thymic function and adaptive immunity in immunodeficiency, we sought to determine the molecular mechanisms that control life and death decisions in TECs. Guided by gene expression profiling, we created mouse models that specifically deleted prosurvival genes in TECs. We found that although BCL-2 and BCL-XL ...[more]