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Determination of Nir (Noc2l) function in epidermis during mouse development by global transcriptome analysis

ABSTRACT: To investigate the role of Nir in epidermis during embryogenesis, we crossed mice harboring conditional Nir alleles with the Krt14-Cre deleter strain, which results in Cre-mediated loss of Nir selectively in epidermis. Transciptome analysis of keratinocytes obtained from control and knock-out mice at E15.5 revealed 4393 genes differentially expressed between Nir knock-out and control mice (p-value<10-2). At E17.5, we found 5673 differentially expressed genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE102277 | GEO | 2018/03/05

REPOSITORIES: GEO

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