A new N6-methyladenosine methyltransferase ZCCHC4 mediates rRNA methylation and mRNA interaction

ABSTRACT: N6-methyladenosine (m6A) plays critical roles in a wide range of physiological and pathological processes, and m6A methyltransferases are still being discovered for different RNA species in mammals. Here report a new m6A methyltransferase ZCCHC4 that methylates ribosomal RNA (rRNA) and interacts with messenger RNA (mRNA), ZCCHC4 has methylation activity on rRNA with a preference for AAC consensus sequence. ZCCHC4 can affect global translation through m6A methylation, mostly on 28S rRNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE102336 | GEO | 2018/09/25

REPOSITORIES: GEO