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Receptor quaternary organization explains G protein-coupled receptor family structure.

ABSTRACT: Purpose: To investigate the quaternary structures of Rhodopsin-family GPCRs. Method: Analyzed 60 receptors from HEK 293T cells. Results: 1) Most of these receptors are monomers. 2) The phylogenetic distribution of dimers suggests that monomers have an evolutionary advantage due to constraints imposed by dimerization on rates of receptor diversification.

ORGANISM(S): Homo sapiens

PROVIDER: GSE102461 | GEO | 2017/08/10

SECONDARY ACCESSION(S): PRJNA397769

REPOSITORIES: GEO

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