Depletion of ZNF185 causes delay of keratinocyte differentiation

ABSTRACT: Development of epidermis includes a complicated program of keratinocyte differentiation. Here we study a new membrane LIM-domain containing Zn-finger protein ZNF185 which is expressed in upper layers of human skin and is up-regulated during keratinocyte differentiation in vitro. Interestingly, depletion of ZNF185 causes delay of keratinocyte differentiation with decreased levels of FLG, LOR, LCEs expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE102613 | GEO | 2018/08/26

REPOSITORIES: GEO