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The gene expression profiles in BALB/3T3 cells during ECTV infection

ABSTRACT: Ectromelia virus (ECTV) has emerged as a valuable model for investigating the host-orthopoxvirus relationship as it relates to pathogenesis and the immune response. We analyzed the transcriptional signatures of BALB/3T3 cells at different times after infection with Ectromelia virus. Mouse Genome 430 2.0 arrays were used to analyze global changes in gene transcripts to generate a pool of genes that was a fold change cut-off of ≥ 1.5 or ≤ 0.5 in infected samples versus non-infected samples. Gene ontology and KEGG pathway analysis showed that the DEGs were involved mainly in immunity, apoptosis, spliceosomes, MAPK signaling and cancer-related pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE102850 | GEO | 2017/08/22

SECONDARY ACCESSION(S): PRJNA399118

REPOSITORIES: GEO

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