Genomics

Dataset Information

0

A molecular roadmap of the aorta-gonad-mesonephros region reveals BMPER as a novel regulator of HSC maturation [AGM]


ABSTRACT: In the developing embryo, haematopoietic stem cells (HSCs) emerge from the aorta-gonad-mesonephros (AGM) region but the molecular regulation of this process is poorly understood. Recently, the progression from E9.5 to E10.5 and polarity along the dorso-ventral axis have been identified as clear demarcations of the supportive HSC niche. To identify novel secreted regulators of HSC maturation, we performed RNA-sequencing over these spatio-temporal transitions in the AGM region, and supportive OP9 cell line.

ORGANISM(S): Mus musculus

PROVIDER: GSE102857 | GEO | 2017/10/30

SECONDARY ACCESSION(S): PRJNA399129

REPOSITORIES: GEO

Similar Datasets

2017-10-30 | GSE102858 | GEO
| E-GEOD-11891 | biostudies-arrayexpress
2008-10-10 | GSE11891 | GEO
| E-GEOD-44181 | biostudies-arrayexpress
2019-03-29 | GSE128971 | GEO
2021-06-01 | GSE125271 | GEO
| S-EPMC5716029 | biostudies-literature
2019-06-01 | GSE130579 | GEO
2018-08-30 | GSE105267 | GEO
2014-10-22 | GSE52094 | GEO