Neuronal EphB1 induces STAT3 activation in astrocytes, which is impaired in ALS models [Mm]

ABSTRACT: Astrocyte  responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanism that determines these different responses are poorly understood. Transcriptional analysis showed that EphB1 induces a protective inflammatory signature in astrocytes, which is distinct from the response evoked by interleukin (IL)-6, which is known to have both pro- and anti-inflammatory properties. We demonstrate that this beneficial EphB1 induced signaling pathway is disrupted in astrocytes derived from human induced pluripotent stem cells (iPSC) of amyotrophic lateral sclerosis (ALS) patients.

ORGANISM(S): Mus musculus

PROVIDER: GSE102903 | GEO | 2017/09/01

SECONDARY ACCESSION(S): PRJNA399192

REPOSITORIES: GEO