Genome-wide transcriptome profile in response to expression of ectopic MYC proteins [RNA-seq]

ABSTRACT: We report the application of RNA-seq digital expression analysis to determine overall expression changes in cells responding to exogenous MYC expression. We found that as a result of expressing several different versions of MYC including a minimal MYC protein, expression of all active genes was amplified linearly in all samples. This suggests that presence of the DNA-binding domain and Myc Box II are sufficient to rescue one of Myc's major phenotypes.

ORGANISM(S): Mus musculus

PROVIDER: GSE102917 | GEO | 2018/08/20

REPOSITORIES: GEO