Transcriptomics,Genomics

Dataset Information

156

Glioblastoma stem cells infected by ZIKA virus


ABSTRACT: We repoted the Glioblastoma stem cells(GSCs) infected by two strains of ZIKA virus, the Brazil and Dakar strains. The ZIKV was added into the medium of GSCs for 48 hours, the RNA was harvested after ZIKV infection. We found that the GSCs up-regulated the Type 1&2 interferons after infected by ZIKV Overall design: 3 GSCs in two status(GSCs vs DGCs) were infected by ZIKV-Brazil and Dakar strains for 48 hours

INSTRUMENT(S): Illumina HiSeq 3000 (Homo sapiens)

SUBMITTER: Zhe Zhu  

PROVIDER: GSE102924 | GEO | 2017-08-23

SECONDARY ACCESSION(S): PRJNA399336

REPOSITORIES: GEO

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Publications


Glioblastoma is a highly lethal brain cancer that frequently recurs in proximity to the original resection cavity. We explored the use of oncolytic virus therapy against glioblastoma with Zika virus (ZIKV), a flavivirus that induces cell death and differentiation of neural precursor cells in the developing fetus. ZIKV preferentially infected and killed glioblastoma stem cells (GSCs) relative to differentiated tumor progeny or normal neuronal cells. The effects against GSCs were not a general pro  ...[more]

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