Transcriptomics,Genomics

Dataset Information

24

Gene expression assessed by genome wide hybridization bead array in intraepithelial lymphocytes (IELs) isolated from small intestinal biopsies of celiac disease patients with active disease and clinical controls


ABSTRACT: Analysis of role of small intestinal intraepithelial lymphocytes (IELs) in the immunopathology of celiac disease Overall design: Five samples of purified IELs from duodenal mucosa of CD patients with active disease, 3 samples of purified IELs of clinical controls were individually subjected to genome-wide hybridization bead array analysis for gene expression.

INSTRUMENT(S): Illumina HumanRef-8 v3.0 expression beadchip

SUBMITTER: Marie-Louise Hammarström  

PROVIDER: GSE102993 | GEO | 2017-08-24

SECONDARY ACCESSION(S): PRJNA399708

REPOSITORIES: GEO

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Publications

Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells.

Pietz Grzegorz G   De Rituparna R   Hedberg Maria M   Sjöberg Veronika V   Sandström Olof O   Hernell Olle O   Hammarström Sten S   Hammarström Marie-Louise ML  

PloS one 20170921 9


Celiac disease is a chronic inflammatory disease of the small intestine mucosa due to permanent intolerance to dietary gluten. The aim was to elucidate the role of small intestinal epithelial cells in the immunopathology of celiac disease in particular the influence of celiac disease-associated bacteria.Duodenal biopsies were collected from children with active celiac disease, treated celiac disease, and clinical controls. Intestinal epithelial cells were purified and analyzed for gene expressio  ...[more]

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