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DNA microarray analysis in hippocampus of Wild-type (WT), AtrxΔE2, and TMPyP4-treated AtrxΔE2 mice.

ABSTRACT: TMPyP4 treatment antagonizes cognitive deficits seen in ATR-X model (AtrxΔE2) mice. Our findings suggest a potential therapeutic strategy to target G-quadruplexes and decrease cognitive impairment associated with ATR-X syndrome.

ORGANISM(S): Mus musculus

PROVIDER: GSE103032 | GEO | 2018/01/28

REPOSITORIES: GEO

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