Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

In vitro study of role of Sigma B in pathogenesis of Avian Reovirus

ABSTRACT: Using microarray technology, we aim to identify in vitro host gene expression for understanding the crosstalk of signaling pathways that leads to the joint pathogenesis in Avian orthoreovirus infection.

ORGANISM(S): Gallus gallus

PROVIDER: GSE103067 | GEO | 2018/05/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

<i>In vitro</i> study on role of σB protein in avian reovirus pathogenesis.

Project description: Not available

| S-EPMC5929409 | biostudies-literature

Changes of miRNA expression profile after avian reovirus infection

Project description:We infected DF-1 cells with avian reovirus, and then used high-throughput sequencing to detect changes in miRNA expression profiles. This research provides a more comprehensive understanding of the interaction between viruses and host cells

2022-06-27 | GSE181193 | GEO

Avian arcopallium

Project description:Avian arcopallium

| PRJNA139189 | ENA

Avian E.coli

Project description:Avian E.coli

| PRJEB11955 | ENA

Avian coronavirus

Project description:Avian virus Avian virus YT-2014 Genome sequencing

| PRJNA267235 | ENA

Changes of miRNA expression profile after avian reovirus infection

Project description:Changes of miRNA expression profile after avian reovirus infection

| PRJNA751037 | ENA

Avian coronavirus

Project description:Avian coronavirus overview

| PRJNA69663 | ENA

Avian reovirus sigma C enhances the mucosal and systemic immune responses elicited by antigen-conjugated lactic acid bacteria.

Project description: Not available

| S-EPMC7115360 | biostudies-literature

Avian E.coli(1)

Project description:Avian E.coli(1)

| PRJEB11956 | ENA

Genome-wide profiling of microRNAs revealing novel insights into mutual interactions mechanism between H9N2 avian influenza virus and avian dendritic cells

Project description:Background：Dendritic cells (DCs), have the most important antigen presenting ability and played an irreplaceable role in recognizing and clearing virus. Antiviral responses must rapidly defend against infection while minimizing inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. MicroRNA, small non-coding RNAs, that can regulate dendritic cells to inhibit the infection and replication of avian influenza virus. Here, we global analyses how avian DCs response to H9N2 avian influenza virus (AIV) and provide a potential mechanism of how avian microRNA defending H9N2 AIV replication. Results： Here, we global analyses how avian DCs response to H9N2 avian influenza virus (AIV) and provide a potential mechanism of how avian microRNA defending H9N2 AIV replication. First, we found that both active and inactive H9N2 AIV enhance the ability of DCs to present antigens and activate T lymphocytes. Next, total microarray analyses suggested that H9N2 AIV stimulation involved in protein localization, nucleotide binding and leukocyte transendothelial migration and MAPK signal pathways. Moreover, we construct 551 transcription factor (TF)-microRNA-mRNA loops based on the above analyses. Furthermore, we found that HA fragment could not activate DCs, while truncated HA highly increased the immune function of DCs by activating ERK and STAT3 signal pathway. Last, our insight research not only gained that gga-miR1644 might target to MBNL2 to enhanced avian DCs in inhibiting virus replication, but also suggested that gga-miR6675 target to the NLS of PB1 to trigger the silencing of PB1 genes and lead to inhibition of H9N2 avian influenza viral replication. All together, our innovative research will shed new light on the roles of avian microRNA in evoking avian DCs and inhibiting virus replication, which will suggest new strategies to combat avian influenza virus.

2017-07-08 | GSE100916 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data