Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture

ABSTRACT: In order to identify the miRNAs in adult Dicer1-CKO Müller glia of the neural retina, we isolated the Müller glia from Rlbp-CreER: Stopf/f-tdTomato/Dicerf/f mice by means of fluorescent activated cell sorting and analyzed their miRNAs using NanoStrings Technologies®. miRNA expression of Dicer1-CKO Müller glia was compared to wild type Müller glia (a re-analyzed sample from GSE94759). We found that all highly expressed miRNAs declined in the Dicer-CKO leading to a disruption in retinal architecture over time.

ORGANISM(S): Mus musculus

PROVIDER: GSE103098 | GEO | 2017/10/31

SECONDARY ACCESSION(S): PRJNA400179

REPOSITORIES: GEO