EZH2-dependent chromatin accessibility changes during B cell differentiation

ABSTRACT: To understand the role of EZH2 in B cell differentiation, EZH2 was inducibly deleted using tamoxifen and B cells stimulated to differentiate with LPS in vivo. After 3 days, EZH2-sufficient and EZH2-deficient naive B cells and plasmablasts were FACS isolated from the spleens and ATAC-seq was performed to identify the chromatin accessibility changes that are programmed by EZH2.

ORGANISM(S): Mus musculus

PROVIDER: GSE103142 | GEO | 2017/12/16

SECONDARY ACCESSION(S): PRJNA400252

REPOSITORIES: GEO