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Genome-wide analysis of gefitinib-tolerant gene expression in single cell-derived clones

ABSTRACT: Analysis of gene expression profiles for gefitinib-tolerant cells derived from single cells. The hypothesis tested here was that a small population of cancer cells contribute to tolerance status in a bulk of EGFR mutated lung cancer cells. Results provide important infromnation of the tolerance to the EGFR tyrosine kinase inhibitor, gefitinib, such as upregualtion of cancer-stemness related genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103155 | GEO | 2018/01/11

SECONDARY ACCESSION(S): PRJNA400371

REPOSITORIES: GEO

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Non-coding mechanisms of tolerance, persistence and resistance to EGFR inhibition in lung cancer [microRNA-seq]

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