MLL1 is essential for retinal development

ABSTRACT: By removing MLL1 from mouse retinal progenitors, we discovered that MLL1 plays multiplex roles in retinal development by regulating: 1) progenitor cell proliferation and cell cycle progression; 2) retinal cell composition; 3) maintenance of horizontal neurons; 4) formation of functional synapses between neuronal layers; and 5) visual function development. Altogether, our results suggest that MLL1 is an indispensable regulator for the development of retinal structure and function.

ORGANISM(S): Mus musculus

PROVIDER: GSE103264 | GEO | 2018/08/15

REPOSITORIES: GEO