Transcriptomics

Dataset Information

33

Transcriptomes in Healthy and Diseased Gingival Tissues


ABSTRACT: We examined gene expression signatures in healthy and diseased gingival tissues in 90 patients. Analysis of the gingival tissue transcriptome in states of periodontal health and disease may reveal novel insights of the pathobiology of periodontitis. Keywords: gingival tissue disease state analysis Overall design: Ninety non-smokers, 63 with chronic and 27 with aggressive periodontitis, each contributing with >=2 “diseased” interproximal papillae (with bleeding on probing, probing pocket depth >=4mm, and clinical attachment loss >=3mm) and a “healthy” papilla, if available (no BoP, PPD<=4mm and CAL<=2mm). RNA was extracted, amplified, reverse transcribed, labeled, and hybridized with AffymetrixU133Plus2.0 arrays. Transcriptome analysis was conducted on a total of 247 samples (from 183 diseased and 64 healthy sites).

REANALYSED by: GSE119128

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Ryan T Demmer   

PROVIDER: GSE10334 | GEO | 2008-12-22

SECONDARY ACCESSION(S): PRJNA105569

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2012-03-27 | E-GEOD-10334 | ArrayExpress
2014-06-03 | E-GEOD-54710 | ArrayExpress
2009-12-22 | GSE16134 | GEO
2015-07-28 | E-GEOD-16134 | ArrayExpress
| GSE80715 | GEO
| GSE79705 | GEO
2010-08-13 | GSE23586 | GEO
2011-06-10 | E-GEOD-23586 | ArrayExpress
| GSE89081 | GEO
2015-07-29 | E-GEOD-16134 | ExpressionAtlas