4sU-seq analysis for tethering hnRNPK to Xist lacking of XR-PID

ABSTRACT: Xist lacking of XR-PID (B-repeat and part of C-repeat) can't recruit the polycomb during X chromsome inactivation. The majoring of Xist-mediated chromosomal silencing wouldn’t be achieved. We found that hnRNPK was the one of main contributors for binding B-repeat of Xist. When we tethered hnRNPK to Xist which lacks of XR-PID region, the silencing and polycomb recruitment are restored.

ORGANISM(S): Mus musculus

PROVIDER: GSE103362 | GEO | 2017/12/08

SECONDARY ACCESSION(S): PRJNA401878

REPOSITORIES: GEO