Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamic transcriptome analysis of human erythroind progenetor cells infected by human Parvovirus B19

ABSTRACT: Human parvovirus B19 (B19V) infection can cause transient aplastic crisis, persistent viremia, and pure red-cell aplasia. In fetuses, B19V infection can result in non-immune hydrops fetalis and fetal death. To systematically investigate the interaction between B19V and erythoid progenetor cells (EPC), microarray was applied to systematically analyze the dynamic transcriptome of CD36+ EPCs during B19V infection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103460 | GEO | 2017/12/07

SECONDARY ACCESSION(S): PRJNA401741

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

qRT-PCR analysis of primary CD36+ cells infected with parvovirus B19

2012-11-04 | GSE42005 | GEO

qRT-PCR analysis of primary CD36+ cells infected with parvovirus B19

Project description:The goal of our present work was to understand the influence parvovirus B19 infection may have on the thyroid hormone signaling pathway, as well as the nuclear receptors (NR) pathway overall. We demonstrated that B19 infection of CD36+ erythroid progenitor cells leads to downregulation of the thyroid hormone receptor α isoform. In addition to that we have shown that B19 infection modulates the expression of other members of the NR superfamily such as estrogen and retinoid receptors. CD36+ cells (StemCell Technologies) were mock-infected or infected with B19, 48 hours post infection cells were collected, total RNA was isolated, and cDNA was obtained as described above. TaqMan® array human nuclear receptors fast 96-well plates obtained from Applied Biosystems (Carlsbad, CA) were utilized in order to assess the differences of 92 nuclear receptors’ expression in mock- and B19-infected CD36+ cells. Relative quantity (RQ) values were calculated using the 2-ΔΔCt method.

2012-11-04 | E-GEOD-42005 | biostudies-arrayexpress

Influenzavirus serotype association to global whole blood transcriptional changes

Project description:Febrile patients PCR positive for H1N1 swine flu, seasonal H1N1 and seasonal H3N2 in nasal swabs and controls consisting of febrile patients with rhinovirus infection or febrile patients of non-viral etiology (nasal swabs PCR negative for common respiratory viruses and blood PCR negative for dengue and parvovirus B19) were assessed consecutively for global transcriptional changes in whole blood

2014-04-01 | GSE29385 | GEO

Ancient human parvovirus B19

Project description:Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans

| PRJEB26712 | ENA

Influenzavirus serotype association to global whole blood transcriptional changes

2014-04-01 | E-GEOD-29385 | biostudies-arrayexpress

Transcriptome profiling of madin-darby canine kidney cells with canine parvovirus 2a persistent infection

Project description:It has been demonstrated that parvovirus infection causing cytotoxicity and immune activation effect in many virus-induced cell lines, however, the underlying mechanisms are not fully understood. To investigate the gene expression signature of host cell after CPV-2 infection, we performed transcriptome profiling of MDCK after persistent infection of CPV-2a using microarray analysis. Uninfected MDCK cells act as negative control. The data show the genes regulated by CPV-2 infection..

2016-12-01 | GSE72397 | GEO

An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis

Project description:We have performed RNA sequencing on kidneys from inclusion body nephropathy-affected mice and compared the data to healthy, uninfected controls. Using a metagenomics approach, we report the identification of the disease causing agent as an atypical virus, mouse kidney parvovirus (MKPV), belonging to a divergent genus of the Parvoviridae. The RNA sequencing also enabled us to assess the host response to MKPV-infection.

2018-07-27 | GSE117710 | GEO

Gene expression profiling of human inflammatory Cardiomyopathy

Project description:Since targeting of specific pathogenic pathways may be more efficient than current unspecific heart failure treatment, we obtained genomewide expression profiles of a DCM subtype characterized by cardiac inflammation (DCMi) in association with parvovirus B19. This study was entirely based on RNA isolated from endomyocardial biopsies so far only rarely used for genomic expression profiling. Keywords: disease state analysis

2006-05-31 | GSE4172 | GEO

Parvovirus B19 NS1 protein induces cell cycle arrest at G2 phase

Project description:We construct two stable UT7/Epo-S1 cell lines which could be inducible expressing B19 NS1 and NS1 TAD2 domain mutation proteins. After treated with or without doxycycline induction, we extract the total RNA for RNA-seq analysis.

2017-03-01 | GSE83525 | GEO

Human parvovirus

Project description:Human parvovirus viral integrations into human cell types

| PRJNA208398 | ENA