BRD4 promotes distinct transcriptional programs in bulk and stem-like prostate tumor cells

ABSTRACT: Genetic knockdown or chemical inhibitors of BRD4 elicited different biological responses in bulk tumor cells in 2D cultures and CSC-enriched tumor-sphere cultures. Gene profiling revealed that BRD4 inhibition affected different sets of genes in two cell contexts. BRD4 drives a CSC-specific transcriptional programs that can be disrupted by chemical inhibitors causing exhaustion and elimination of prostate CSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103504 | GEO | 2017/09/06

SECONDARY ACCESSION(S): PRJNA401762

REPOSITORIES: GEO