Transcriptomics,Genomics

Dataset Information

33

SIRT1 expression effect on migration and invasion of gastric cancer cells


ABSTRACT: Analysis of BGC-823 gastric cancer cells with SIRT1 overexpression or knockdown. SIRT1, a NAD+-dependent protein deacetylase, exerts inhibitory effects on migration and invasion of gastric cancer. Results provide insight into the role of SIRT1 in the metastasis of gastric cancer. Overall design: Four groups: Group 1, Stable lentivirus infected BGC-823 cells with the lentiviral expressing vector. Group 2, Stable lentivirus infected BGC-823 cells with the lentiviral expressing vector containing SIRT1 cDNA sequence. Group 3, Stable lentivirus infected BGC-823 cells with the lentiviral vector containing interference control sequence. Group 4, Stable lentivirus infected BGC-823 cells with the lentiviral vector containing interference sequence targeting SIRT1.

INSTRUMENT(S): Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)

SUBMITTER: Guoying Dong 

PROVIDER: GSE103519 | GEO | 2017-09-07

SECONDARY ACCESSION(S): PRJNA401828

REPOSITORIES: GEO

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