Transcriptomics,Genomics

Dataset Information

141

γδ T cells producing IL-17A regulate adipose Treg homeostasis and thermogenesis


ABSTRACT: RNA sequencing of PLZF+ and PLZF- γδ T cell subsets from adipose tissue for gene expression analysis Overall design: PLZF+ and PLZF- γδ T cells were sorted from adipose tissue of PLZF-GFP mice for subsequent RNA sequencing and gene-expression analysis. Two replicates for each subset pooled from 10 mice each were used for the study.

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

SUBMITTER: Tal Shay  

PROVIDER: GSE103742 | GEO | 2018-05-10

REPOSITORIES: GEO

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Publications


γδ T cells are situated at barrier sites and guard the body from infection and damage. However, little is known about their roles outside of host defense in nonbarrier tissues. Here, we characterize a highly enriched tissue-resident population of γδ T cells in adipose tissue that regulate age-dependent regulatory T cell (Treg) expansion and control core body temperature in response to environmental fluctuations. Mechanistically, innate PLZF+ γδ T cells produced tumor necrosis factor and interleu  ...[more]

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