Olig2 targetome in SHH subgroup of medulloblastoma

ABSTRACT: Several basic helix-loop-helix (bHLH) transcription factors are upregulated in Sonic Hedgehog subgroup of medulloblastoma (SHH MB). Olig2, a neural bHLH transcription factor known to regulate differentiation of neural cell populations, is broadly expressed in mouse models of SHH MB. ChIP-Seq of Olig2 revealed its binding to a large number of sites near genes known to promote SHH MB tumorigenesis, suggesting a potential role for Olig2 in regulating transcriptional programme of MB.

ORGANISM(S): Mus musculus

PROVIDER: GSE103824 | GEO | 2024/03/23

REPOSITORIES: GEO