Transcriptomics,Genomics

Dataset Information

45

The olfactory molecular snapshot in aged Tg2576 Alzheimer´s disease mouse model


ABSTRACT: Olfaction is often deregulated in Alzheimer´s disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegeneration of olfactory structures in Tg2576 mice. For that, we have applied proteome- and transcriptome-wide approaches to probe molecular disturbances in the olfactory bulb (OB) dissected from aged Tg2576 mice (18 months of age) respect to age matched wild-type (WT) littermates. Overall design: Olfactory bulbs from 3 WT mice vs olfactory bulbs from 3 Tg2576 transgenic mice

INSTRUMENT(S): [Clariom_S_Mouse] Affymetrix Mouse Clariom S Array

SUBMITTER: Victor Segura  

PROVIDER: GSE103835 | GEO | 2018-02-14

REPOSITORIES: GEO

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Publications

Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer's Disease Mouse Model.

Palomino-Alonso Maialen M   Lachén-Montes Mercedes M   González-Morales Andrea A   Ausín Karina K   Pérez-Mediavilla Alberto A   Fernández-Irigoyen Joaquín J   Santamaría Enrique E  

International journal of molecular sciences 20171027 11


Olfaction is often deregulated in Alzheimer's disease (AD) patients, and is also impaired in transgenic Tg2576 AD mice, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegeneration of olfactory structures in aged Tg2576 mice. For that, we have applied proteome- and transcriptome-wide approaches to probe molecular disturbances in the olfactory bulb (OB) dissected from aged Tg2576 m  ...[more]

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