Differential Gene Expression in MDA-MB231 from transduction of cells with shRNA targeting CDK19 and CDK8

ABSTRACT: When CDK19 was initially discovered, it was assumed that CDK19 played a redundant role to CDK8 because they share 84% amino acid sequence similarity. However, biological clues such as CDK19s different chromosomal location and its more limited tissue distribution suggested a role distinct from CDK8 To investigate whether CDK19 and CDK8 had distinct biological functions in Triple-Negative breast cancer, we knocked down CDK19 and CDK8 in MDA-MB231 and examined differences in the resulting gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103851 | GEO | 2020/09/13

REPOSITORIES: GEO