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Silencing of ultra-conserved long non-coding RNA Uc.291 causes delay of keratinocyte differentiation

ABSTRACT: Development of the skin includes a complicated program of cellular differentiation. Here, we study the role of Uc.291, a long non-coding RNA derived from ultra-conserved region, upregulated in suprabasal layer of the skin and during in vitro differentiation of keratinocytes. Depletion of Uc.291 causes delay of keratinocyte differentiation with decreased levels of the expression of epidermal differentiation complex (EDC) genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103890 | GEO | 2020/01/08

REPOSITORIES: GEO

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