Transcriptomics,Genomics

Dataset Information

46

CD157 positive endothleilal stem cells in the liver


ABSTRACT: Analysis of primary liver endothelial cells (ECs) isolated from WT mice. Results provide insight into the heterogeniety of liver ECs. Overall design: To explore endothelial stem cell marker, DNA microarray analysis was performed to compare the gene expression profiles between EC-SP cells and EC-MP cells, and among CD157+CD200+ ECs, CD157-CD200+ ECs, and CD157-CD200- ECs from adult liver. Three independent samples were collected.

INSTRUMENT(S): Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version)

SUBMITTER: Jun-ichi Suehiro 

PROVIDER: GSE103936 | GEO | 2018-02-07

REPOSITORIES: GEO

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Publications


The generation of new blood vessels via angiogenesis is critical for meeting tissue oxygen demands. A role for adult stem cells in this process remains unclear. Here, we identified CD157 (bst1, bone marrow stromal antigen 1) as a marker of tissue-resident vascular endothelial stem cells (VESCs) in large arteries and veins of numerous mouse organs. Single CD157+ VESCs form colonies in vitro and generate donor-derived portal vein, sinusoids, and central vein endothelial cells upon transplantation  ...[more]

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