Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease

ABSTRACT: Maternal hyperglycemia increases the risk of CHD and is further sensitized by haploinsufficiency of Notch1 supporting a gene-environment interaction model. To gain insights into chromatin accessible status by which hyperglycemia affects molecular pathways regulating cardiac development, we performed ATAC-seq on embryonic AV cushion mesenchymal cells maintained in normal and high glucose.

ORGANISM(S): Mus musculus

PROVIDER: GSE104520 | GEO | 2017/10/03

SECONDARY ACCESSION(S): PRJNA412907

REPOSITORIES: GEO