Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE104811 | GEO | 2018/10/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

Project description:Proper functioning of the lymphatic system is required for normal immune response, fluid balance and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure correct formation of lymphatic vessels; however, whether epigenetic regulation is involved in this process remains largely unknown. We report that epigenetic priming by the Disruptor of telomeric silencing 1-like (DOT1L) in endothelial cell (EC) is indispensable for generation and function of lymphatic endothelial cells (LECs). Mechanistically, loss function of DOT1L leads to reduction of H3K79 di-methylation and expression of the genes important for LEC development and function. Thus, our study establishes DOT1L-mediated transcriptional regulation in ECs plays an important role in differentiation and function of LECs.

2018-10-10 | GSE104810 | GEO

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

Project description:Proper functioning of the lymphatic system is required for normal immune response, fluid balance and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure correct formation of lymphatic vessels; however, whether epigenetic regulation is involved in this process remains largely unknown. We report that epigenetic priming by the Disruptor of telomeric silencing 1-like (DOT1L) in endothelial cell (EC) is indispensable for generation and function of lymphatic endothelial cells (LECs). Loss function of DOT1L leads to reduction of H3K79 di-methylation and expression of the genes important for LEC development and function. Thus, our study establishes DOT1L-mediated transcriptional regulation in ECs plays an important role in differentiation and function of LECs.

2018-10-10 | GSE104809 | GEO

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells

| PRJNA413915 | ENA

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [ChIP-Seq]

| PRJNA413924 | ENA

Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

Project description:Genome-wide mapping of H3K79me2 in EPZ5676-treated lymphatic endothelial cells [RNA-Seq]

| PRJNA413925 | ENA

Lung lymphatic endothelial cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-02 | GSE213744 | GEO

Genome-wide mapping of promoter-enhancer interactions with HiCap

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-07-06 | E-GEOD-60495 | biostudies-arrayexpress

Genome-wide mapping of fission yeast

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-13 | GSE95047 | GEO

Genome-wide mapping of Hif-1Î± binding sites in zebrafish

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-22 | E-GEOD-70886 | biostudies-arrayexpress

Effects of HHV8 infection in lymphatic endothelial cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-09-30 | GSE16357 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data