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Expression data MCF-7 Breast cancer cells with Graphene Oxide and Graphene nitrite Treatments

ABSTRACT: Breast cancer is one of the fatal diseases, Graphene has a property that can be used for Imaging and Therapy. Global gene expression changes leading to these changes were investigated presently in Breast cancer subtypes. The pathological staging of the cancers is compared to global gene expression profiles. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE104939 | GEO | 2021/03/31

REPOSITORIES: GEO

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Expression data MCF-7 Breast cancer cells with Graphene Oxide and Graphene nitrite Treatments

Project description:Expression data MCF-7 Breast cancer cells with Graphene Oxide and Graphene nitrite Treatments

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Expression data from retina and reinoblastoma tumour samples

Project description:Retinoblastoma (Rb) progresses from retina to noninvasive Rb and then into invasive Rb. Global gene expression changes leading to these changes were investigated presently in Rb subtypes. The pathological staging of the tumours is compared to global gene expression profiles. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

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A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide

Project description:This study investigates transcriptomic differences in the lung and liver after pulmonary exposure to two Graphene based materials with similar physical properties, but different surface chemistry. Female C57BL/6 mouse were exposed by a single intratracheal instillation of 0, 18, 54 or 162 μg/mouse of graphene oxide (GO) or reduced graphene oxide (rGO). Pulmonary and hepatic transcriptional changes were compared to identify commonly and uniquely perturbed functions and pathways by GO and rGO. These changes were then related to previously analyzed endpoints. GO exposure induced more differentially expressed genes, affected more functions, and perturbed more pathways compared to rGO, both in the lung and liver.

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Identification of protein corona on graphene oxide in B medium

Project description:As antimicrobials, graphene materials (GMs) may have advantages over traditional antibiotics due to their physical mechanisms of action which ensure less chance of development of microbial resistance. However, the fundamental question as to whether the antibacterial mechanism of GMs originates from penetration by their sharp edges or wrapping of the cell membrane, or from a combination of these and other mechanisms, remains controversial. In this study, we show both experimentally and theoretically that GMs with high surface oxygen content (SOC) predominantly attach in parallel to the bacterial cell surface when in the suspension phase. The interaction mode shifts to perpendicular interaction when the SOC reaches a threshold of ~ 0.3 (the atomic percent of O in the total atoms). However, neither mode necessarily kills bacteria. Rather, bactericidal activity depends on the interaction of GMs with surrounding biomolecules. Proteomic study shows that protein corona forms on the surface graphene oxide in LB medium, thus explain the different antibacterial activity in different culture medium.

2023-05-10 | PXD027909 | Pride

Graphene Oxide Substrate Promotes Neurotrophic Factor Secretion and Survival of Human Schwann-Like Adipose Mesenchymal Stromal Cells - RNAseq

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Methylation arrays (MethylationEPIC) of human lung epithelial BEAS-2B cells exposed to reduced graphene oxide

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Extremely low frequency electromagnetic fields enhance neuronal differentiation of human mesenchymal stem cells on graphene-based substrate

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