Dataset Information


Transcription Factor Substitution during the Evolution of Fungal Ribosome Regulation_expression profiling

ABSTRACT: Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, in Candida albicans, the RP regulon is controlled by the Myb-domain protein Tbf1 working in conjunction with Cbf1. These two factors bind both the promoters of RP genes and the rDNA locus; Tbf1 activates transcription at these loci and is essential. Orthologs of Tbf1 bind TTAGGG telomeric repeats in most eukaryotes, and TTAGGG cis-elements are present upstream of RP genes in plants and fungi, suggesting that Tbf1 was involved in both functions in ancestral eukaryotes. In all Hemiascomycetes, Rap1 substituted Tbf1 at telomeres and in the S. cerevisiae lineage this substitution also occurred independently at RP genes, illustrating the extreme adaptability and flexibility of transcriptional regulatory networks. Keywords: Expression profiling Overall design: Expression profiling of tetracycline addition time-course in the tetO-TBF1/tbf1 conditional mutant.

INSTRUMENT(S): Candida albicans expression array

ORGANISM(S): Candida albicans  

SUBMITTER: Hugo Lavoie  

PROVIDER: GSE10499 | GEO | 2008-03-14



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