Transcriptomics,Genomics

Dataset Information

81

Gene Expression Profiling of melanoma cell lines after shRNA-mediated knockdown of JMJD2C or LSD1


ABSTRACT: We hypothesize that knockdown of the H3K9 demethylases JMJD2C or LSD1 results in decreased proliferation and tumorigenic potential Overall design: Examination of gene expression in two melanoma cell lines following knockdown of JMJD2C or LSD1

INSTRUMENT(S): BGISEQ-500 (Homo sapiens)

SUBMITTER: Maja Milanovic  

PROVIDER: GSE105137 | GEO | 2017-12-04

SECONDARY ACCESSION(S): PRJNA414916

REPOSITORIES: GEO

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Publications


Oncogene-induced senescence, e.g., in melanocytic nevi, terminates the expansion of pre-malignant cells via transcriptional silencing of proliferation-related genes due to decoration of their promoters with repressive trimethylated histone H3 lysine 9 (H3K9) marks. We show here that structurally distinct H3K9-active demethylases-the lysine-specific demethylase-1 (LSD1) and several Jumonji C domain-containing moieties (such as JMJD2C)-disable senescence and permit Ras/Braf-evoked transformation.  ...[more]

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