Genomics

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Genes regulated by AML1/ETO in U937 cells


ABSTRACT: Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used microarrays to identify genes differentially expressed in U937 cells expressing AML1/ETO compared to vector transfected U937 cells. Keywords: Transcriptional regulation

ORGANISM(S): Homo sapiens

PROVIDER: GSE10520 | GEO | 2008/11/28

SECONDARY ACCESSION(S): PRJNA108941

REPOSITORIES: GEO

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