Expression analysis of THP1 cells following shRNA knock-down of RUVBL2

ABSTRACT: We used an inducible shRNA system and RNA-Seq to examine gene expression changes in acute myeloid leukemia THP1 cells following silencing of RUVBL2. RUVBL2 is a AAA+ ATPase that functions in a number of cellular processes, including chromatin remodeling and trnascriptional control, and is critical for survival of acute myeloid leukemia cells and in vivo disease progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE105253 | GEO | 2018/10/31

REPOSITORIES: GEO