Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells [MCF-7]

ABSTRACT: SREBP1 is a master regulator of lipogenic gene expression. However, the underlying mechanisms of SREBP1-mediated metastasis has not been thoroughly elucidated.We involved microarray to analyze the differences of gene expression profiling between breast cancer cells with stable SREBP1 knockdown and the control cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE105405 | GEO | 2017/10/21

SECONDARY ACCESSION(S): PRJNA415127

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells [MDA-MB-231]

Project description:SREBP1 is a master regulator of lipogenic gene expression. However, the underlying mechanisms of SREBP1-mediated metastasis has not been thoroughly elucidated.We involved microarray to analyze the differences of gene expression profiling between breast cancer cells with stable SREBP1 knockdown and the control cells.

2017-10-24 | GSE105791 | GEO

Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells [MCF-7]

Project description:Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells [MCF-7]

| PRJNA415127 | ENA

Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells

Project description:Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells

| PRJNA415724 | ENA

Dynamics of SREBP1 binding to DNA in mouse liver

Project description:To systematically understand how the circadian clock and the nutrient-driven rhythm integrate to regulate SREBP1 activity, we evaluated genome-wide the binding of SREBP1 to its targets along the day in wild-type (WT) C57BL/6mice. The recruitment of SREBP1 to the DNA showed a highly circadian behaviour, with a maximum during the fed status. However, the temporal expression of SREBP1 targets was not always synchronized with its binding. In particular, a different phase of expression was observed for SREBP1 target genes depending on their function, suggesting the involvement of other transcription factors in their regulation. The proper temporal expression pattern of these genes was dramatically changed in Bmal1KO mice upon time-restricted feeding, in spite of the rhythmic, although slightly delayed, binding of SREBP1. Our results show that besides the nutrient-driven regulation of SREBP1 nuclear translocation, a second layer of modulation of SREBP1 transcriptional activity exists and is strongly dependent from the circadian core clock. This system allows to fine tune the expression timing of SREBP1 target genes, thus helping to temporally separate the different physiological processes in which these genes are involved. 6 samples examined, 6 SREBP1 samples, as well as 6 Polr2b and 6 input samples from GEO series GSE35788 CycliX Consortium was a contributor to this submission.

2014-03-10 | E-GEOD-48375 | biostudies-arrayexpress

Dynamics of SREBP1 binding to DNA in mouse liver

2014-03-10 | GSE48375 | GEO

Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-10-25 | GSE106144 | GEO

Caspase-4 mediates SREBP1 activation in macrophages

Project description:We identified caspase-4/S1P/SREBP1 pathway that is activated in LPS-treated macrophages. To analyze the functions of caspase-4 and SREBP1 in gene expression in macrophages, we analyzed the effects of deletions of Casp4 and Srebf1 in bone marrow-derived macrophages by RNA-seq.

2023-01-09 | GSE208374 | GEO

Gene regulated by Srebp1 and c-Myc during reprogramming

Project description:To identify genes regulated by Srebp1 and c-Myc during reprogramming, we performed genome-wide transcriptome profiling in mouse embryonic fibroblasts infected with SKO, SKOM or SKOM plus Srebp1.

2014-11-29 | GSE63705 | GEO

Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells [MDA-MB-231]

Project description:Differences of gene expression profiling of breast cancer cells with stable SREBP1 knockdown and the control cells [MDA-MB-231]

| PRJNA415414 | ENA

mTORC1 couples SREBP-dependent transcription and splicing of de novo lipid synthesis enzymes via FAM120A de novo lipid synthesis enzymes via FAM120A

Project description:FAM120A as a transcriptional co-activator that couples transcription and splicing of lipid synthesis enzymes downstream of mTORC1-SRPK2 signaling. Mechanistically, the mTORC1-activated SRPK2 phosphorylates a splicing factor SRSF1, enhancing its binding to FAM120A. FAM120A directly interacts with a lipogenic transcription factor SREBP1 at active promoters, thereby bridging newly transcribed lipogenic genes to the RNA splicing machinery.

2022-07-02 | GSE207172 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data