Polycomb CBX7 represses expression of tumor suppressor genes

ABSTRACT: Polycomb CBX7 was stably expressed in embryonal carcinoma cells in order to identify target genes. The study was specifically geared toward unveiling gene targets that are susceptible to DNA hypermethylation in adult cancer. A number of CBX7 target tumor suppressor genes were thereby identified and used in further studies to characterize the mechanism surrounding CBX7 mediated gene suppression. Keywords: CBX7 target gene identification

ORGANISM(S): Homo sapiens

PROVIDER: GSE10541 | GEO | 2009/09/23

SECONDARY ACCESSION(S): PRJNA107899

REPOSITORIES: GEO