Dataset Information


H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Igor Dolgalev 

PROVIDER: GSE105456 | GEO | 2017-10-23

SECONDARY ACCESSION(S): S-EPMC6554729 GSE105444PRJNA415202 GSE105455S-EPMC5749543


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H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.

Nancy Patrice P   Siewiera Johan J   Rizzuto Gabrielle G   Tagliani Elisa E   Osokine Ivan I   Manandhar Priyanka P   Dolgalev Igor I   Clementi Caterina C   Tsirigos Aristotelis A   Erlebacher Adrian A  

The Journal of clinical investigation 20171127 1

Uncovering the causes of pregnancy complications such as preterm labor requires greater insight into how the uterus remains in a noncontractile state until term and then surmounts this state to enter labor. Here, we show that dynamic generation and erasure of the repressive histone modification tri-methyl histone H3 lysine 27 (H3K27me3) in decidual stromal cells dictate both elements of pregnancy success in mice. In early gestation, H3K27me3-induced transcriptional silencing of select gene targe  ...[more]

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